Patented Brain Neuromodulation Platform
The Challenge of Treating Brain Disorders
When treating epilepsy, Alzheimer’s, Parkinson’s disease, obsessive-compulsive disorder (OCD), anxiety, mood disorders, and PTSD, existing psychiatric and neurological protocols are often ineffective. A large portion of the population remains undertreated or suffers from significant side effects.
- 40–60% of patients do not fully respond to medications
- Over 60% experience adverse effects
- Many face issues with dependence, withdrawal, and long-term use
- Psychotherapy, while helpful, is costly, time-consuming, and inconsistent in quality
- 40–50% of patients either do not want or do not benefit from psychological treatment
Current Neuromodulation Approaches Are Lacking
Deep Brain Stimulation (DBS)
DBS is effective and focused but invasive. It requires drilling into the cranium and implanting electrodes in targeted brain regions. Though widely accepted for essential tremors, Parkinson’s, dystonia, and OCD, it is still under investigation for depression and other conditions.
Repetitive Transcranial Magnetic Stimulation (rTMS)
rTMS is non-invasive and FDA-approved for depression. It stimulates the cortex but only reaches about 3–4 cm deep and over a wide area. While widely available and gaining insurance coverage, it’s difficult to combine with neuroimaging and offers limited targeting precision.
Superficial Electrical and Magnetic Stimulation Devices
Examples include CES and tDCS. These are inexpensive and widely distributed but superficial and poorly targeted. FDA approval often relies on legacy similarity, and many claims remain unproven in clinical trials. They are generally not reimbursed by insurers.
Our Patented Solution
We have developed a proprietary Low-Intensity Focused Ultrasound Pulsation (LIFUP) platform to modulate brain function non-invasively, without harmful or irreversible effects. Our technology enables:
- Targeting of specific neuronal circuits using structural and functional MRI
- Real-time identification of malfunctioning circuits using fMRI feedback
- Circuit repair through selective stimulation or inhibition using LIFUP
Key features of the BrainSonix solution are:
- Hardware: Custom BrainSonix transducer and model housing (patent issued)
- Software: Proprietary BrainSonix software for dosimetry and exposure quantification
- Integration: fully compatible with fMRI
- Intellectual property: Patented device design; two use patents issued